Regulatory T Cells in Multiple Sclerosis Diagnostics-What Do We Know So Far?

Area of Science:

• Neuroimmunology
• Autoimmune Diseases

Background:

• Multiple sclerosis (MS) is a central nervous system autoimmune disorder characterized by inflammation.
• Acute MS symptoms can arise during the relapsing phase of the disease.

Purpose of the Study:

• To evaluate the role of regulatory T cells (Tregs) in the pathogenesis of multiple sclerosis (MS).

Main Methods:

• Systematic review of scholarly articles from PubMed, PsycINFO, and CINAHL.
• Search terms included 'regulatory T cells', 'multiple sclerosis', and 'current knowledge'.
• Article selection limited to publications between 2010 and 2020.

Main Results:

• Regulatory T cells (Tregs) are involved in the pathogenesis of MS.
• Evidence from animal models and environmental factors supports Treg alterations in MS.
• Specific Treg subsets contributing to MS pathogenesis are not yet fully understood.

Conclusions:

• A significant link exists between Tregs and MS activity.
• Targeting Tregs presents a potential strategy for novel MS treatment approaches.
• Further investigation is required to elucidate the precise mechanisms by which Tregs influence MS pathogenesis.