Related Experiment Video

Updated: Jul 5, 2025

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

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Myocardial Calcium Handling in Type 2 Diabetes: A Novel Therapeutic Target

Abhishek Dattani1, Anvesha Singh1, Gerry P McCann1

  • 1Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Leicester LE3 9QP, UK.

Journal of Cardiovascular Development and Disease
|January 22, 2024
PubMed

Insights

Type 2 diabetes (T2D) leads to heart failure through impaired myocardial calcium handling. This review explores T2D cardiomyopathy mechanisms and novel therapeutic targets for calcium dysregulation.

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • Type 2 diabetes (T2D) is a global health crisis with rising prevalence.
  • Heart failure is a significant complication of T2D, impacting patient outcomes.
  • Myocardial calcium handling is implicated in T2D-associated cardiomyopathy.

Purpose of the Study:

  • To review the physiological basis of cardiomyocyte calcium handling.
  • To examine novel imaging techniques for quantifying myocardial calcium uptake.
  • To synthesize evidence on impaired calcium handling in T2D and discuss therapeutic strategies.

Main Methods:

  • Literature review of physiological concepts in cardiomyocyte calcium handling.
  • Analysis of pre-clinical models and in vivo studies on T2D.
  • Discussion of emerging therapeutic approaches targeting myocardial calcium.

Main Results:

  • Cardiomyopathy in T2D is linked to dysregulated myocardial calcium handling.
  • Evidence for impaired calcium handling in T2D is supported by pre-clinical and in vivo data.
  • Novel imaging techniques aid in quantifying myocardial calcium uptake.

Conclusions:

  • Dysregulated myocardial calcium handling is a key mechanism in T2D cardiomyopathy.
  • Targeting calcium handling pathways presents a promising therapeutic avenue for T2D complications.
  • Further research is needed to translate these findings into clinical practice.
Keywords:
calcium handlingdiabetesmanganese-enhanced MRI

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