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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Updated: Jul 5, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Secondary developmental glaucoma.

Sushmita Kaushik1, Jyoti Singh1, Surinder Singh Pandav1

  • 1Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Taiwan Journal of Ophthalmology
|January 22, 2024
PubMed
Summary
This summary is machine-generated.

Childhood glaucoma stems from impaired trabecular meshwork outflow. Understanding genetic causes of Anterior Segment Dysgeneses (ASD) aids early diagnosis and management of developmental glaucoma.

Keywords:
Anterior Segment DysgenesesSecondary non acquired childhood glaucoma

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Area of Science:

  • Ophthalmology
  • Genetics
  • Developmental Biology

Background:

  • Childhood glaucoma pathophysiology involves impaired trabecular meshwork outflow.
  • Anterior Segment Dysgeneses (ASD) are congenital anomalies causing secondary developmental glaucoma.
  • Genetic factors significantly influence anterior segment development.

Purpose of the Study:

  • To review ocular and systemic conditions causing secondary developmental glaucoma.
  • To provide an overview of phenotypes, diagnosis, and management principles for ASD-related glaucoma.
  • To highlight the role of molecular research in understanding ASD and glaucoma.

Main Methods:

  • Literature review of conditions causing secondary developmental glaucoma.
  • Summary of genetic underpinnings of anterior segment development.
  • Overview of clinical presentations and management strategies.

Main Results:

  • Identifying genetic causes of ASD is crucial for recognizing disease spectrums.
  • Molecular research elucidates developmental mechanisms in ASD.
  • Genetic characterization enables diagnostic and screening test development.

Conclusions:

  • Understanding the genetic basis of ASD is key to early glaucoma detection and prevention of optic nerve damage.
  • Genetic insights facilitate risk stratification for future pregnancies and prenatal testing.
  • Comprehensive reviews of ASD-related glaucoma aid clinical management and genetic counseling.