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Updated: Jul 5, 2025
Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats
Published on: May 27, 2021
Microlesion Effect Induced by Electrode Implantation in the Posteroventral Globus Pallidus Interna for Severe
Galih Indra Permana1,2, Takashi Morishita1, Hideaki Tanaka1
1Department of Neurosurgery, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
Background:
Tourette syndrome (TS) is a neurologic condition characterized by motor and phonic tics. Dystonic tics, including blepharospasm, are considered atypical or unusual in severe TS.
Case Report:
We report a severe case of TS with facial dystonic tics resembling blepharospasm in which the microlesion effect and a sustained therapeutic effect was observed with bilateral globus pallidus interna (GPi) deep brain stimulation (DBS).
Discussion:
Bilateral GPi DBS can be beneficial for blepharospasm-like tics and severe symptoms of TS. The improvements seen can be explained by the microlesion effect induced by DBS lead placement in the GPi.
