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Updated: Aug 6, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
Published on: March 20, 2018
[Method for the experimental study of factors modifying carcinogenesis]
Abstract:
Research in factors modifying carcinogenesis is closely associated with studies on complex multifactorial systems. Mathematical methods of planning multifactorial experiments should be used which assures a higher reliability of the results and elicits additional information. An analysis of the data on the modifying effect of aniline, sodium alkylsulfate and lead nitrite on nitrosomethylamine-induced carcinogenesis carried out on the basis of the newly-developed method showed its advantages over the existing ones.
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