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Quantifying Phase-Amplitude Modulation in Neural Data
Victoria Subritzky-Katz1, Aaron L Sampson1, Erik Emeric1
1Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, USA.
Abstract:
Phase-amplitude modulation (the modulation of the amplitude of higher frequency oscillations by the phase of lower frequency oscillations) is a specific type of cross-frequency coupling that has been observed in neural recordings from multiple species in a range of behavioral contexts. Given its potential importance, care must be taken with how it is measured and quantified. Previous studies have quantified phase-amplitude modulation by measuring the distance of the amplitude distribution from a uniform distribution. While this method is of general applicability, it is not targeted to the specific modulation pattern frequently observed with low-frequency oscillations. Here we develop a new method that has increased specificity to detect modulation in the sinusoidal shape commonly observed in neural data.
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