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Primary Sclerosing Cholangitis: Diagnostic Criteria
Nora Cazzagon1,2, Samantha Sarcognato3, Elisa Catanzaro1,2
1Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy.
Abstract:
Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by inflammation and fibrosis of intra- and/or extrahepatic bile ducts leading to the formation of multifocal strictures alternated to bile duct dilatations. The diagnosis of the most common subtype of the disease, the large duct PSC, is based on the presence of elevation of cholestatic indices, the association of typical cholangiographic findings assessed by magnetic resonance cholangiography and the exclusion of causes of secondary sclerosing cholangitis. Liver biopsy is not routinely applied for the diagnosis of large duct PSC but is mandatory in the case of suspicion of small duct PSC or overlap with autoimmune hepatitis.
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