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Updated: Jul 5, 2025
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Correlation Between Risk Factors, Degree of Vascular Restenosis, and Inflammatory Factors After Interventional
Liang Hao1, Mingming Gao, Wei Guo
1Department of Neurosurgery, The Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.
Insights
Lifestyle factors like obesity, smoking, and drinking, along with hypertension and diabetes, are linked to poor outcomes after stroke intervention. Inflammatory markers can predict vascular restenosis post-treatment.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Inflammation Research
Background:
- Interventional stroke treatment aims to restore blood flow but can be complicated by vascular restenosis.
- Identifying factors influencing treatment efficacy and restenosis is crucial for improving patient outcomes.
Purpose of the Study:
- To investigate the correlation between pre-existing risk factors, the degree of vascular restenosis, and inflammatory markers following interventional stroke treatment.
- To evaluate the predictive value of inflammatory factors for vascular restenosis after stroke intervention.
Main Methods:
- Retrospective analysis of 96 stroke patients undergoing interventional therapy with a 1-year follow-up.
- Univariate and multivariate regression analyses to identify factors associated with interventional stroke efficacy.
- Analysis of inflammatory factor levels (interleukin 6, interleukin 2, TNF-α, C-reactive protein) for predicting vascular restenosis.
Main Results:
- Obesity (BMI ≥ 25.51 kg/m²), smoking, alcohol consumption, hypertension, and diabetes were significantly associated with poor postoperative outcomes (P <0.05).
- Vascular stenosis severity correlated with elevated levels of interleukin 6, interleukin 2, TNF-α, and C-reactive protein (P <0.001).
- Combined inflammatory factor assessment demonstrated high predictive accuracy for postoperative restenosis (AUC = 0.882, sensitivity = 84.30%, specificity = 81.20%).
Conclusions:
- Risk factors including obesity, smoking, alcohol use, hypertension, and diabetes negatively impact outcomes of interventional stroke treatment.
- Preoperative inflammatory marker levels are valuable predictors of postoperative vascular restenosis, aiding in risk stratification and management.
Objective:
To study the correlation between risk factors, degree of vascular restenosis, and inflammatory factors after interventional treatment for stroke.
Methods:
The clinical data of 96 stroke patients who received interventional therapy in our hospital from April 2020 to June 2021 were selected for retrospective study, and the postoperative follow-up was 1 year. Univariate and multivariate regression were used to analyze identified factors associated with interventional stroke efficacy. At the same time, the value of inflammatory factor levels in predicting vascular restenosis after interventional stroke was analyzed.
Results:
According to our findings, several risk factors, including body mass index ≥ 25.51 kg/m 2 , smoking, drinking, hypertension, and diabetes, were identified as contributors to poor postoperative efficacy following stroke intervention ( P <0.05). Furthermore, a notable association was observed between the severity of vascular stenosis ( P <0.001) and the levels of interleukin 6, interleukin 2, TNF-α, and C-reactive protein. The combined assessment of these serum inflammatory factors exhibited excellent predictive capability for postoperative vascular restenosis and stenosis severity, yielding a sensitivity of 84.30%, a specificity of 81.20%, and an area under the curve of 0.882.
Conclusions:
Obesity, smoking, alcohol consumption, hypertension, and diabetes have been found to be associated with suboptimal outcomes following interventional treatment for stroke. The assessment of preoperative levels of inflammatory factors holds promise in predicting the likelihood of postoperative restenosis to a certain degree.
