Characteristics and outcomes of patients with tricuspid regurgitation and advanced heart failure

Related Experiment Video

Updated: Jul 5, 2025

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
08:43

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation

Published on: March 17, 2023

679

Matteo Pagnesi1, Mauro Riccardi1, Mauro Chiarito2,3

  • 1Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological sciences and Public Health, University of Brescia, Brescia.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|January 22, 2024
PubMed

Insights

Severe tricuspid regurgitation is linked to increased mortality in advanced heart failure patients. This study identified factors associated with severe tricuspid regurgitation, highlighting its prognostic significance.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Echocardiography

Background:

  • Tricuspid regurgitation (TR) is common in heart failure (HF).
  • The prognostic impact of TR in advanced HF requires further elucidation.
  • Understanding TR's role is crucial for managing complex HF patients.

Purpose of the Study:

  • To assess the role of tricuspid regurgitation in advanced heart failure.
  • To identify clinical factors associated with severe TR.
  • To evaluate the association between TR severity and mortality.

Main Methods:

  • Observational, multicenter study (HELP-HF registry) of advanced HF patients.
  • Stratification based on TR severity: none/mild, moderate, severe.
  • Analysis of factors associated with severe TR and its impact on all-cause mortality.

Main Results:

  • 1085 patients included; 18.8% had severe TR.
  • Atrial fibrillation, prior valve surgery, furosemide dose, LVEF, mitral regurgitation, and pulmonary hypertension were linked to severe TR.
  • 1-year mortality was 37.1% for severe TR vs. 21.4% for none/mild TR (P < 0.001).
  • Severe TR independently predicted higher all-cause mortality (aHR 1.38, P=0.042).

Conclusions:

  • Clinical and echocardiographic factors predict severe TR in advanced HF.
  • Severe TR is an independent predictor of mortality in this population.
  • Management strategies for advanced HF should consider TR severity.
Abstract

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