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Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Related Experiment Video

Updated: Jul 5, 2025

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

Polyphenols as Potential Geroprotectors.

Ekaterina Proshkina¹, Liubov Koval¹, Elena Platonova¹

¹Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology of the Federal Research Center "Komi Scientific Centre" of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia.

Antioxidants & Redox Signaling

|January 22, 2024

Summary

This summary is machine-generated.

Polyphenols show promise as geroprotectors, potentially slowing aging and extending lifespan by acting on conserved molecular pathways. Further research is needed to confirm their effectiveness and safety in humans for healthspan extension.

Keywords:

aging geroprotector hormesis life span polyphenols

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Published on: June 10, 2022

Area of Science:

Biochemistry
Gerontology
Nutritional Science

Background:

Diets rich in polyphenols offer health benefits.
Polyphenols possess geroprotective potential, slowing aging processes and promoting longevity.
Evidence suggests phytochemicals influence healthspan and aging biomarkers.

Purpose of the Study:

To comprehensively analyze individual polyphenols for their adherence to geroprotector criteria.
To evaluate the potential of polyphenols in slowing aging and promoting longevity.
To identify polyphenols with the highest geroprotective potential.

Main Methods:

Analysis of data from experimental models, clinical trials, and epidemiological studies.
Review of 62 polyphenols shown to increase lifespan and improve aging biomarkers in animal models.
Examination of molecular mechanisms including hormesis, redox homeostasis, and epigenetic regulation.

Main Results:

Sixty-two polyphenols demonstrated lifespan extension and improved aging biomarkers in animal models.
Polyphenols act via conserved molecular mechanisms like hormesis, redox homeostasis, and anti-inflammatory pathways.
Chlorogenic acid, quercetin, epicatechin, genistein, resveratrol, and curcumin show high geroprotective potential.

Conclusions:

Certain polyphenols show potential for preventing and treating age-related diseases like cancer, metabolic, and cardiovascular conditions.
Unambiguous human data on polyphenol effectiveness and safety for healthspan extension is lacking.
Further research is crucial to understand long-term effects, bioavailability, and interactions of polyphenols in humans.