Related Experiment Video
Updated: Jul 5, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
Atorvastatin Effect on COVID-19 Outcomes: A Propensity Score Matched Study on Hospitalized Patients
Mohamad Amin Pourhoseingholi1, Omid Yazdani1, Mehdi Azizmohammad Looha2
1Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Atorvastatin use in COVID-19 patients was associated with reduced in-hospital mortality but did not affect intensive care unit (ICU) admission. Further research is needed to confirm these findings on COVID-19 outcomes.
Area of Science:
- Cardiology
- Infectious Diseases
- Pharmacology
Background:
- Investigated the impact of atorvastatin on COVID-19 patient outcomes, including survival, ICU admission, and hospital length of stay.
- Retrospective analysis of COVID-19 inpatients admitted between March 2020 and March 2021.
Purpose of the Study:
- To determine the association between atorvastatin use and prognosis in COVID-19 patients.
- To evaluate the drug's effect on mortality, ICU admission, and length of hospital stay.
Main Methods:
- Retrospective cohort study involving 4322 COVID-19 patients.
- Propensity score matching (PSM) used for 1:1 patient-control balancing.
- Analysis of unadjusted and adjusted effects of atorvastatin on COVID-19 prognosis.
Main Results:
- Atorvastatin use was linked to decreased COVID-19 mortality (HR: 0.80; 95% CI: 0.68-0.95).
- No significant association found between atorvastatin and ICU admission (HR: 1.21; 95% CI: 0.99-1.47).
- Atorvastatin group had a significantly longer hospital stay (p = 0.003); combination therapy with enoxaparin improved survival.
Conclusions:
- Atorvastatin may reduce in-hospital mortality for COVID-19 patients.
- Considered a potentially beneficial add-on therapy for COVID-19.
- Randomized trials are recommended to validate these observational findings.
More Related Videos
Related Concept Videos
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
Time Course of Drug Effect
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Heart Failure Drugs: β-Blockers
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...

