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A new phenylspirodrimane derivative from the deep-sea-derived fungus Stachybotrys chartarum FS705
Shuo Wang1,2, Saini Li2, Yuchan Chen2
1Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems and Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China.
Abstract:
A new phenylspirodrimane derivative named stachybotrysin A (1), together with four known analogues (2-5) were isolated and purified from the solid culture of the deep-sea-derived Stachybotrys chartarum FS705. Their structures were determined by comprehensive spectroscopic analysis and the absolute configuration was evaluated by theoretical ECD calculations. Compounds 1-5 were evaluated for their cytotoxic, antibacterial and α-glucosidase inhibitory activities. The results showed that compound 2 displayed mild cytotoxicity with IC50 values in the range of 8.88 ∼ 22.73 µM against four human tumour cell lines, SF-268, MCF-7, HepG-2, and A549. Compound 1 showed strong α-glucosidase inhibitory activity with an IC50 value of 20.68 µM. Compounds 4 and 5 exhibited weak antibacterial activity against Bacillus subtilis.
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