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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Preventive Healthcare Services01:30

Preventive Healthcare Services

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Levels of Health Promotion and Illness Prevention01:26

Levels of Health Promotion and Illness Prevention

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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
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Green Cancer Prevention and Beyond.

Sharon A Ross1, Nancy J Emenaker1, Amit Kumar1

  • 1Division of Cancer Prevention, Nutritional Sciences Research Group, National Cancer Institute, Rockville, Maryland.

Cancer Prevention Research (Philadelphia, Pa.)
|January 22, 2024
PubMed
Summary
This summary is machine-generated.

Green chemoprevention uses whole plant foods and extracts to prevent cancer. Research shows broccoli sprouts and black raspberries offer cancer-protective benefits with low toxicity in humans.

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Area of Science:

  • Oncology
  • Nutritional Science
  • Preventive Medicine

Background:

  • Green chemoprevention, introduced in 2012, utilizes whole plant foods and extracts for cancer prevention.
  • Early research focused on broccoli sprouts and black raspberries, demonstrating dose-responsive, low-toxicity effects in animals and humans.
  • Dietary supplements represent a potential next-generation approach to green cancer prevention.

Approach:

  • This review highlights refined concepts and proof-of-principle research in green chemoprevention.
  • It examines whole foods like broccoli sprouts and black raspberries for their cancer-preventive activities.
  • A recent trial evaluated broccoli seed/sprout extract for detoxifying tobacco carcinogens in smokers.

Key Points:

  • Challenges include optimizing dose, duration, delivery, control groups, and standardization of plant-based interventions.
  • Identifying molecular targets and selecting high-risk cohorts are crucial for study design.
  • Precision green cancer prevention aims for robust human data linking plant compounds to cancer risk reduction.

Conclusions:

  • Green chemoprevention, using whole foods and extracts, shows promise for cancer risk reduction.
  • Dietary supplements derived from plants offer a potential avenue for next-generation cancer prevention strategies.
  • Future research should focus on controlled human studies to validate plant-based cancer prevention targets.