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Related Experiment Video

Updated: Jul 5, 2025

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

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Reviving Intervertebral Discs: Treating Degeneration Using Advanced Delivery Systems.

Hong Zhang¹, Xiaorong Yang¹, Yiheng Huang¹

¹School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.

Molecular Pharmaceutics

|January 22, 2024

Summary

Delivery systems enhance therapies for intervertebral disc degeneration (IVDD), improving treatment efficacy by targeting the intervertebral disc (IVD). These systems offer a promising approach to manage IVDD and alleviate associated spinal problems.

Keywords:

bioactive substances cell therapy delivery systems drug gene therapy intervertebral disc degeneration

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Area of Science:

Biomedical Engineering
Regenerative Medicine
Spinal Health

Background:

Intervertebral disc degeneration (IVDD) is a major cause of low back pain and reduced quality of life.
Current conservative and surgical treatments for IVDD have limitations in fully restoring disc function.
Delivery systems offer a novel approach to enhance therapeutic agent efficacy for IVDD.

Purpose of the Study:

To review the structure, function, and pathophysiology of intervertebral discs (IVDs).
To highlight the role of drug-based and bioactive-substance-based delivery systems in treating IVDD.
To discuss the limitations and future prospects of delivery-system-based therapies for IVDD.

Main Methods:

Review of existing literature on intervertebral disc degeneration (IVDD) and delivery systems.
Categorization of therapeutic agents used in delivery systems (drugs, bioactive substances, genes, cells).
Analysis of the advantages of delivery systems in overcoming therapeutic limitations.

Main Results:

Delivery systems effectively deliver therapeutic agents to the intervertebral disc (IVD), increasing local concentration and reducing leakage.
Drug-based systems include small molecules, NSAIDs, and steroids.
Bioactive-substance-based systems involve growth factors, chemokines, and platelet-rich plasma.

Conclusions:

Delivery-system-based therapies show significant potential for inhibiting IVDD and promoting IVD regeneration.
Combination of therapeutic agents and advanced delivery systems offers promising future treatment strategies for IVDD.
Further research is needed to optimize these combined approaches for clinical application.