Related Experiment Video
Updated: Jul 5, 2025
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Unveiling Liquid Gold: Lymph as an HPV Marker in OPSCC to Guide Treatment Decisions
Nicholas B Shannon1,2, N Gopalakrishna Iyer1,2
1Department of Head and Neck Surgery, Singapore General Hospital and National Cancer Centre Singapore, Singapore.
Abstract:
Distinguishing low- versus high-risk HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) is pivotal for tailoring treatment. Liquid biopsy, measuring cell-free HPV-DNA in serum and saliva, assesses treatment response and early-recurrence risk. Postoperative lymphatic fluid may better guide future adjuvant therapy decisions due to its proximity to primary lesions and lymph nodes. See related article by Earland et al., p. 1409.
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