[Thrombocyte substitution. I. Indications and clinical use of thrombocyte transfusion]

The clinical use of the transfusion of thrombocytes, its indication and problems in the long-term substitution of thrombocytes are explained. Out of the side effects the alloimmunisation against antigens of the HLA-system in the long-term substitution is of greatest importance. A substitution of thrombocytes is indicated in the disturbances of formation. The substitution shall be performed prophylactically in the acute leukaemia and aplasing therapy. When an increased destruction of thrombocytes is existing, other therapy principles are important. Recommendations are given for the prophylactic substitution of thrombocytes. The analysis of the transfusion of 320 concentrates of thrombocytes is reported.