Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pathophysiology of reperfusion].

W Schaper

    Zeitschrift Fur Kardiologie
    |January 1, 1986
    PubMed
    Summary

    Reperfusion effectively salvages heart muscle after coronary occlusion, especially with good collateral blood flow. Prompt reperfusion within an hour is crucial for saving ischemic heart tissue.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The temporal and spatial distribution of macrophage subpopulations during arteriogenesis.

    Current vascular pharmacology·2013
    Same author

    Involvement of neuronal NO synthase in collateral artery growth.

    Indian journal of biochemistry & biophysics·2011
    Same author

    Collateral vessels reduce mortality.

    European heart journal·2011
    Same author

    Cerebral arteriogenesis is enhanced by pharmacological as well as fluid-shear-stress activation of the Trpv4 calcium channel.

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2011
    Same author

    Development and role of coronary collaterals.

    Trends in cardiovascular medicine·2011
    Same author

    Calcium-dependent signalling is essential during collateral growth in the pig hind limb-ischemia model.

    Journal of molecular and cellular cardiology·2010

    Area of Science:

    • Cardiovascular Physiology
    • Ischemic Heart Disease Research

    Context:

    • Investigating myocardial salvage after coronary occlusion.
    • Examining factors influencing tolerance to ischemia: time, myocardial oxygen demand (MVO2), and collateral blood flow.
    • Utilizing diverse mammalian models (dogs, pigs, cats, rabbits, guinea pigs, rats) to study variations in collateral circulation and MVO2.

    Purpose:

    • To determine the impact of time, MVO2, and collateral blood flow on myocardial salvage via reperfusion.
    • To compare the tolerance to ischemia and infarction rates across different species with varying collateral blood flow capacities.
    • To assess the effect of increased MVO2 on ischemic tolerance in canines.

    Summary:

    • Hearts with higher collateral blood flow exhibit greater tolerance to ischemia.
    • Species ranked by collateral flow (guinea pig > cat > dog > pig > rat) mirrored their resistance to infarction.
    • In guinea pigs, high collateral flow prevented infarction from coronary ligation; pigs and rats showed rapid infarction.
    • Increased MVO2 (via vagotomy) reduced ischemic tolerance in canines.
    • Reperfusion is the most potent intervention for salvaging ischemic myocardium if performed during reversible injury.

    Impact:

    • Highlights reperfusion as a critical intervention for myocardial salvage.
    • Establishes a correlation between collateral blood flow and ischemic tolerance across species.
    • Suggests the window for effective reperfusion may be limited (approx. 1 hour) in individuals with low collateral flow, especially with tachycardia or reduced perfusion pressure.
    • Provides insights into species-specific responses to ischemia and reperfusion, relevant for preclinical research and understanding human heart disease.

    Related Experiment Videos