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Updated: Jul 5, 2025
Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
Published on: July 14, 2010
Changes of synaptic vesicles in three-dimensional synapse models by treatment with umbelliferone in
Ga-Young Choi1, Eunyoung Moon1, Hyosung Choi1
1Center of Research Equipment, Korea Basic Science Institute, Cheongju, 28119, Republic of Korea.
Abstract:
The neuroprotective effects of umbelliferone (UMB) were visualized in three-dimensional (3D) images on vesicle density changes of organotypic hippocampal slice tissues (OHSCs) induced by scopolamine by high voltage electron microscopy. Observations revealed that the number of vesicles decreased in OHSCs induced by scopolamine, and UMB was found to inhibit scopolamine-induced reduction in vesicles, resulting in an increase in vesicle count. These 3D models provide valuable insight for understanding the increase of synapse vesicles in hippocampal tissues treated with UMB.
