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Rheb1 is required for limb growth through regulating chondrogenesis in growth plate

Yuwei Zhang1, Jiaxin Wen1, Ruijun Lai2

  • 1School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.

Cell and Tissue Research
|January 22, 2024
PubMed
Summary

Ras homology enriched in the brain 1 (Rheb1) is crucial for limb bone growth. Deleting Rheb1 in limb mesenchymal cells caused dwarfism and abnormal growth plate development in mice.

Keywords:
Chondrocyte ProliferationChondrocyte maturationChondrogenesisRheb1mTORC1

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