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Ultrasound study of right ventricular myocardial perfusion and functional changes in hypertrophic cardiomyopathy
Shan Cao1,2, Lingjie Yang1,2, Liyun Liu1,2
1Xinjiang Key Laboratory of Ultrasound Medicine, No. 137 Li Yu Shan South Road, Urumqi, China.
Insights
Right ventricular (RV) myocardial perfusion and strain are reduced in hypertrophic cardiomyopathy (HCM) patients. This study found a positive correlation between RV perfusion and strain, indicating potential microcirculation impairment.
Area of Science:
- Cardiology
- Echocardiography
- Cardiovascular Imaging
Background:
- Hypertrophic cardiomyopathy (HCM) can affect right ventricular (RV) function.
- Assessing RV myocardial perfusion and function is crucial for HCM management.
Purpose of the Study:
- To evaluate changes in RV myocardial perfusion and function in HCM patients using myocardial contrast echocardiography (MCE) and 2D speckle-tracking echocardiography (2D-STE).
- To explore the relationship between RV myocardial perfusion and myocardial strain in HCM.
Main Methods:
- Conventional ultrasound, MCE, and 2D-STE were performed on 29 HCM patients and 21 healthy controls.
- Analysis included RV myocardial perfusion, RV global strain, RV free wall strain, and segmental strain.
- Correlation analysis investigated the relationship between RV perfusion and strain in HCM patients.
Main Results:
- HCM patients exhibited decreased regional RV myocardial perfusion compared to controls.
- RV function was impaired in HCM patients, with reduced RV global strain and segmental strain.
- A positive correlation was observed between RV myocardial perfusion and strain in HCM patients.
Conclusions:
- Regional myocardial perfusion and strain are reduced in the RV of HCM patients.
- The positive correlation suggests that impaired myocardial microcirculation may contribute to reduced myocardial strain in HCM.
Background:
To evaluate the changes of right ventricular (RV) myocardial perfusion and function in patients with hypertrophic cardiomyopathy (HCM) by myocardial contrast echocardiography (MCE) and speckle tracking (2D-STE), and to explore the relationship between RV myocardial perfusion and strain.
Methods:
Conventional ultrasound, MCE and 2D-STE were performed on 29 HCM patients and 21 healthy subjects to analyze RV myocardial perfusion, RV global strain, RV free wall strain, and strain of each segment. The correlation between RV myocardial perfusion and strain was further analyzed in HCM patients.
Results:
MCE results showed that the regional myocardial perfusion of the RV in HCM patients was decreased. Compared with the normal control group, the mean slope (β) in the middle and apical segments of the RV free wall, and the peak intensity (A), β, myocardial blood flow (MBF) of the ventricular septum decreased in HCM patients (P < 0.05). RV function was impaired in HCM patients. The RV global strain (RV GLS), and the strain of RV free wall and each segment were lower than those in the normal control group (P < 0.05). Correlation analysis showed that there was a certain correlation between RV myocardial perfusion and strain, such as the β of the whole RV in HCM group had a positive correlation with the strain of the middle segment of the interventricular septum (r = 0.550, P = 0.002).
Conclusions:
The regional myocardial perfusion and strain of the RV in HCM patients are reduced, and there is a positive correlation between them, suggesting that the reduction of myocardial strain may be related to the impairment of myocardial microcirculation.
