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Updated: Jul 5, 2025

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
Published on: February 10, 2014
Effects of Aging on Osteosynthesis at Bone-Implant Interfaces
Alexa K Pius1, Masakazu Toya1, Qi Gao1
1Department of Orthopaedic Surgery, School of Medicine, Stanford University, Stanford, CA 94063, USA.
Abstract:
Joint replacement is a common surgery and is predominantly utilized for treatment of osteoarthritis in the aging population. The longevity of many of these implants depends on bony ingrowth. Here, we provide an overview of current techniques in osteogenesis (inducing bone growth onto an implant), which is affected by aging and inflammation. In this review we cover the biologic underpinnings of these processes as well as the clinical applications. Overall, aging has a significant effect at the cellular and macroscopic level that impacts osteosynthesis at bone-metal interfaces after joint arthroplasty; potential solutions include targeting prolonged inflammation, preventing microbial adhesion, and enhancing osteoinductive and osteoconductive properties.
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