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Regulation of Angiogenesis by Non-Coding RNAs in Cancer

Zhiyue Su1, Wenshu Li1, Zhe Lei1

  • 1Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Biomolecules
|January 23, 2024
PubMed

Insights

Non-coding RNAs regulate tumor angiogenesis, a key process in cancer growth and spread. Targeting these RNAs offers a promising new strategy for anti-angiogenic cancer therapies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are critical regulators of gene expression.
  • Dysregulation of ncRNAs is increasingly linked to tumor angiogenesis, a vital process for tumor growth, metastasis, and cancer mortality.
  • Understanding the molecular mechanisms of ncRNA-mediated angiogenesis is crucial for developing effective cancer treatments.

Purpose of the Study:

  • To provide a comprehensive overview of how various ncRNAs regulate tumor angiogenesis.
  • To discuss novel therapeutic strategies utilizing ncRNAs for anti-angiogenic cancer therapy.

Main Methods:

  • Literature review of studies investigating the role of non-coding RNAs in tumor angiogenesis.
  • Analysis of molecular mechanisms of ncRNA regulation in angiogenesis.
  • Exploration of emerging anti-angiogenic therapeutic approaches targeting ncRNAs.

Main Results:

  • Non-coding RNAs play multifaceted roles in regulating angiogenesis through epigenetic, transcriptional, and post-transcriptional mechanisms.
  • Specific ncRNAs have been identified as key players in promoting or inhibiting angiogenesis in various cancers.
  • Emerging evidence supports the potential of ncRNAs as biomarkers and therapeutic targets for anti-angiogenic interventions.

Conclusions:

  • Non-coding RNAs are pivotal regulators of tumor angiogenesis, impacting cancer progression and patient outcomes.
  • Targeting ncRNAs represents a promising avenue for developing novel anti-angiogenic therapies to combat cancer.
  • Further research into ncRNA functions and therapeutic applications is warranted to advance cancer treatment strategies.
Keywords:
circRNAlncRNAmiRNAtumor angiogenesis

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