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Updated: Jul 5, 2025

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
Published on: April 26, 2016
Beneficial Use of the Combination of Gemcitabine and Dacarbazine in Advanced Soft Tissue Sarcomas: Real-World Data
Ibon Gurruchaga Sotés1,2, M Carmen Gómez-Mateo3, María Eugenia Ortega Izquierdo2,4
1Department of Medical Oncology, Hospital Universitario de Navarra, 31008 Pamplona, Spain.
Background:
The combination of gemcitabine and dacarbazine has exhibited efficacy in terms of progression-free survival (PFS) and overall survival (OS) for aSTSs, albeit without robust confirmation from larger clinical trials.
Methods:
We conducted a retrospective study in a single institution involving aSTS patients treated with gemcitabine and dacarbazine.
Results:
95 patients were assessed, pointing to a benefit in PFS of 3.5 months and an OS of 14.2 months. Patients with translocated histotypes had better PFS, while those with platelet-lymphocyte ratios (PLRs) surpassing a specific threshold or lower albumin levels had poorer overall survival.
Conclusions:
This study validates previous findings from three phase I-II trials, affirming the utility of this treatment approach in routine clinical practice.
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