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Adiponectin C1q/Tumor Necrosis Factor-Related Protein 13 (CTRP13) Protects against Renal Inflammation and Fibrosis in

Yongxia Li1,2, Wenzhe Wang2, Changxuan Liu2

  • 1Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Biomedicines
|January 23, 2024
PubMed

Insights

C1q/tumor necrosis factor-related protein 13 (CTRP13) combats renal inflammation and fibrosis in obstructive nephropathy by inhibiting key signaling pathways. This discovery offers new therapeutic avenues for chronic kidney disease (CKD).

Area of Science:

  • Nephrology
  • Molecular Biology
  • Pathology

Background:

  • Obstructive nephropathy involves renal inflammation and fibrosis, but mechanisms remain unclear.
  • C1q/tumor necrosis factor-related protein 13 (CTRP13) role in kidney disease is under investigation.
  • Reduced CTRP13 levels are observed in renal fibrosis patients and models.

Purpose of the Study:

  • Investigate CTRP13's effects on renal inflammation and fibrosis in obstructive nephropathy.
  • Elucidate the underlying molecular mechanisms of CTRP13's action.
  • Assess CTRP13 as a potential therapeutic target for chronic kidney disease (CKD).

Main Methods:

  • Established a mouse unilateral ureteral obstruction (UUO) model for renal dysfunction.
  • Utilized hematoxylin-eosin staining, immunofluorescence, Western blotting, and RT-qPCR.
  • Administered recombinant CTRP13 to assess its therapeutic potential.

Main Results:

  • CTRP13 expression was decreased in renal fibrosis patients and UUO mice.
  • CTRP13 administration reversed UUO-induced renal dysfunction, fibrosis, and tubular injury.
  • CTRP13 inhibited extracellular matrix proteins and pro-inflammatory mediators.
  • CTRP13's protective effects were linked to inactivating TGF-β/Smad and NF-κB p65 pathways.

Conclusions:

  • CTRP13 plays a crucial role in mitigating renal inflammation and fibrosis.
  • CTRP13 demonstrates therapeutic potential for obstructive nephropathy and CKD.
  • Inactivation of TGF-β/Smad and NF-κB pathways mediates CTRP13's protective effects.
Keywords:
CTRP13fibrosisinflammationkidney

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