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Anti-Aging Drugs and the Related Signal Pathways

Nannan Du1,2, Ruigang Yang1,2,3, Shengrong Jiang4

  • 1Frontier Biotechnology Laboratory, Beijing Institute of Biotechnology, Beijing 100071, China.

Biomedicines
|January 23, 2024
PubMed

Insights

This review explores key aging pathways and drugs targeting them. It highlights how drugs like rapamycin and metformin offer accessible strategies for aging alleviation and mechanism-based interventions.

Area of Science:

  • Gerontology and molecular biology
  • Focuses on the biological mechanisms of aging and therapeutic interventions.

Background:

  • Aging is a complex process linked to chronic diseases, affecting individuals from molecular to systemic levels.
  • Various interventions exist, including dietary changes, exercise, and pharmaceuticals, with anti-aging drugs offering ease of use and accessibility.

Purpose of the Study:

  • To review critical aging-related signal pathways and their targeted drugs.
  • To provide insights for developing mechanism-based anti-aging strategies.

Main Methods:

  • Comprehensive literature search of PubMed, Web of Science, EBSCO, and Cochrane Library databases up to May 31, 2022.
  • Identified 15,983 relevant articles for analysis.

Main Results:

  • Six key aging pathways identified: mTOR, AMPK, nutrient signaling, SIRT1, telomere length regulation, and GSK-3/energy metabolism.
  • Representative drugs targeting these pathways include rapamycin, metformin, acarbose, NAD+, lithium, and NSAIDs.

Conclusions:

  • Anti-aging drugs targeting distinct pathways can alleviate aging.
  • Understanding pathway crosstalk is crucial for advancing mechanism-based anti-aging therapies.
Keywords:
NAD+NSAIDSacarboseaginganti-aging drugslithiummetforminrapamycinsignal pathway

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