Overcoming Chemotherapy Resistance in Metastatic Cancer: A Comprehensive Review
Maryam Eslami1,2,3, Omid Memarsadeghi1,2, Ali Davarpanah1,2,3
1Applied Biotechnology Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran 1949635881, Iran.
Biomedicines
|January 23, 2024
Summary
Overcoming chemotherapy resistance in metastatic cancer is crucial. This review details molecular mechanisms and strategies like combination therapy, targeted treatments, and immunotherapy to improve patient outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Chemotherapy resistance complicates metastatic cancer management.
- Understanding resistance mechanisms is vital for effective treatment.
- Current chemotherapy approaches face significant challenges.
Purpose of the Study:
- To provide a comprehensive academic review of strategies to overcome chemotherapy resistance in metastatic cancer.
- To explore molecular mechanisms underlying chemotherapy resistance.
- To discuss current and emerging therapeutic strategies.
Main Methods:
- Literature review of academic publications and clinical trials.
- Analysis of molecular mechanisms including genetic alterations, epigenetic modifications, drug metabolism, and survival pathways.
- Examination of therapeutic strategies such as combination therapy, targeted therapy, immunotherapy, and drug repurposing.
Main Results:
- Chemotherapy resistance involves genetic, epigenetic, metabolic, and signaling pathway alterations.
- Promising strategies include combination therapies, targeted agents, immunotherapies, and drug repurposing.
- Predictive biomarkers and personalized medicine approaches are key for guiding treatment.
Conclusions:
- A multi-faceted approach is necessary to combat chemotherapy resistance.
- Understanding molecular mechanisms is fundamental for developing novel therapeutic strategies.
- Translating research findings into clinical practice is essential for improving metastatic cancer treatment outcomes.
Keywords:
chemotherapy resistanceclinical trialscombination therapydrug repurposingimmunotherapymetastatic cancer cellspersonalized medicinepredictive biomarkerstargeted therapyMore Related Videos
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