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Updated: Jul 5, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Chronic Kidney Disease Associated with Ischemic Heart Disease: To What Extent Do Biomarkers Help?
Maria-Ruxandra Cepoi1,2, Stefania Teodora Duca1,2, Adriana Chetran1,2
1Department of Internal Medicine, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Insights
Chronic kidney disease (CKD) and ischemic heart disease share common pathways. Identifying cardiorenal biomarkers is key for diagnosing and managing these interconnected conditions, improving patient outcomes.
Area of Science:
- Nephrology
- Cardiology
- Biomarker Research
Background:
- Chronic kidney disease (CKD) involves renal dysfunction and inflammation, leading to significant cardiovascular complications.
- Cardiovascular disease, particularly ischemic heart disease, is the primary cause of mortality in CKD patients.
- The cardiorenal link necessitates understanding shared pathophysiological mechanisms.
Purpose of the Study:
- To explore the complex relationship between CKD and ischemic heart disease.
- To investigate the utility of specific cardiorenal biomarkers in diagnosing and prognosing these conditions.
Main Methods:
- Review of existing literature on cardiorenal biomarkers.
- Analysis of pathophysiological links between CKD and ischemic heart disease.
- Focus on biomarkers such as cardiac troponin, natriuretic peptides, galectin-3, copeptin, FGF23/Klotho, ST2, and GDF-15.
Main Results:
- CKD and ischemic heart disease share common inflammatory and toxic pathways.
- Specific biomarkers show potential for assessing cardiorenal dysfunction.
- Early identification of cardiorenal dysfunction is critical for risk stratification.
Conclusions:
- Understanding the cardiorenal axis is crucial for managing CKD patients.
- Biomarker-guided strategies can improve diagnosis, prognosis, and risk assessment.
- Further research into these biomarkers may lead to targeted therapies.
Abstract:
Chronic kidney disease represents a complex and multifaceted pathology characterized by the presence of structural or functional renal anomalies associated with a persistent reduction in renal function. As the disease progresses, complications arise due to the chronic inflammatory syndrome, hydro-electrolytic disorders, and toxicity secondary to the uremic environment. Cardiovascular complications are the leading cause of death for these patients. Ischemic cardiac pathology can be both a consequence and complication of chronic kidney disease, highlighting the need to identify specific cardiorenal dysfunction biomarkers targeting pathophysiological mechanisms common to both conditions. This identification is crucial for establishing accurate diagnoses, prognoses, and risk stratifications for patients. This work is intended to elucidate the intricate relationship between chronic kidney disease and ischemic heart disease and to investigate the roles of cardiorenal biomarkers, including cardiac troponin, natriuretic peptides, galectin-3, copeptin, fibroblast growth factor 23 and its co-receptor Klotho, soluble suppression of tumorigenicity 2, and plasma growth differentiation factor 15.
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