Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same journal

Correction: Yalçın et al. Impact of SGLT2 Inhibitors on Cardiovascular Risk Scores, Metabolic Parameters, and Laboratory Profiles in Type 2 Diabetes. <i>Life</i> 2025, <i>15</i>, 722.

Life (Basel, Switzerland)·2026

Same journal

Correction: Schubert et al. Minimally Invasive Ablation Strategies for Renal Cell Carcinoma Patients Ineligible for Surgery. <i>Life</i> 2026, <i>16</i>, 73.

Life (Basel, Switzerland)·2026

Same journal

Blood Group Antigen Combinations and COVID-19: Complexity, Associations and Possible Clinical Relevance.

Life (Basel, Switzerland)·2026

Same journal

Beyond HPV in Eastern Europe: Genotype Distribution, Molecular Biomarkers, Vaginal Microbiome, and Implications for Cervical Cancer Prevention.

Life (Basel, Switzerland)·2026

Same journal

Therapeutic Effects of <i>Scutellaria baicalensis</i> Georgi Extract and Baicalein on Olfactory Dysfunction and Neurobehavioral Alterations in a Methimazole-Induced Injury Model.

Life (Basel, Switzerland)·2026

Same journal

The Effects of Unstable Strength Training on Lower Limb Stability in Adolescent Volleyball Players in China.

Life (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Jul 5, 2025

Detection of Detergent-sensitive Interactions Between Membrane Proteins

Detection of Detergent-sensitive Interactions Between Membrane Proteins

Published on: March 7, 2018

Network Proteins of Human Sortilin1, Its Expression and Targetability Using Lycopene.

Arun H S Kumar¹

¹Stemcology, School of Veterinary Medicine, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.

Life (Basel, Switzerland)

|January 23, 2024

Summary

Sortilin1 (SORT1) is linked to tissue fibrosis and calcification. This study identified IGF2R and GRN as key networks and found that empagliflozin, sitagliptin, and lycopene can effectively target SORT1 for potential therapeutic use.

Keywords:

Sortilin1 fibrosis lycopene microcalcification unstable plaque

More Related Videos

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

Related Experiment Videos

Last Updated: Jul 5, 2025

Detection of Detergent-sensitive Interactions Between Membrane Proteins

Detection of Detergent-sensitive Interactions Between Membrane Proteins

Published on: March 7, 2018

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

Area of Science:

Cardiovascular Biology
Molecular Medicine
Drug Discovery

Background:

Sortilin1 (SORT1) is a protein transporter implicated in tissue fibrosis and calcification.
Targeting SORT1 presents a potential therapeutic strategy for cardiovascular conditions.

Purpose of the Study:

To investigate the protein-protein interaction network of human SORT1.
To assess the targetability of SORT1 using existing pharmaceuticals and nutraceuticals.

Main Methods:

Protein-protein interaction networks were identified using the String database.
Molecular docking simulations (AutoDock Vina) were performed to evaluate drug targetability.
Tissue expression profiles and binding pocket analyses were conducted.

Main Results:

IGF2R and GRN were identified as high-affinity SORT1 interaction networks relevant to fibrosis and calcification.
SORT1 expression is prominent in adipocytes, epithelial cells, monocytes, and cardiomyocytes.
Empagliflozin, sitagliptin, and lycopene demonstrated superior affinity and concentration affinity ratios for targeting SORT1.

Conclusions:

IGF2R and GRN are key SORT1 networks involved in regulating tissue fibrosis and microcalcification.
Approved therapeutics (empagliflozin, sitagliptin) and nutraceuticals (lycopene) show promise for targeting SORT1.
Further clinical trials are warranted to evaluate efficacy in reducing cardiovascular microcalcification.