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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Serum Uric Acid Associates with Systemic Complement C3 Activation in Severe ANCA-Associated Renal Vasculitides

Eva Baier1, Ingmar Alexander Kluge2, Samy Hakroush2,3,4

  • 1Department of Nephrology and Rheumatology, University Medical Center Göttingen, 37075 Göttingen, Germany.

International Journal of Molecular Sciences
|January 23, 2024
PubMed

Insights

Serum uric acid (UA) levels are inversely correlated with complement C3 and C4d deposition in ANCA-associated renal vasculitis. These findings highlight UA

Area of Science:

  • Nephrology
  • Immunology
  • Metabolic Research

Background:

  • The complement system's role in ANCA-associated renal vasculitis pathogenesis is established.
  • The immunometabolic implications, particularly concerning serum uric acid (UA) levels, remain underexplored.

Purpose of the Study:

  • To investigate the relationship between serum UA levels and clinical/histopathological features in ANCA-associated renal vasculitis.
  • To explore the immunometabolic aspects of this kidney disease.

Main Methods:

  • Retrospective analysis of 34 patients with biopsy-proven ANCA-associated renal vasculitis.
  • Correlation of serum UA levels with complement C3/C4d deposition, disease severity, and histopathological findings (tubulitis, interstitial fibrosis).
  • Subgroup analysis including critically ill, MPO-ANCA, and PR3-ANCA patients.

Main Results:

  • Inverse correlation found between serum UA and complement C3 levels in the total cohort and critically ill subgroup.
  • Intrarenal complement C4d deposition in venules correlated with serum UA levels.
  • Serum UA levels associated with tubulitis and interstitial fibrosis, particularly in PR3-ANCA patients.

Conclusions:

  • Serum UA levels are linked to complement activation and histopathological damage in ANCA-associated renal vasculitis.
  • UA may serve as a potential biomarker or reflect underlying metabolic disturbances in this condition.
  • Further research into UA's role could offer new insights into disease pathogenesis and management.

Keywords:
ANCA-associated renal vasculitisanti-neutrophil cytoplasmic antibodycomplement C3complement activationinnate immunityserum uric acid

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