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Y-Box Binding Protein 1: Unraveling the Multifaceted Role in Cancer Development and Therapeutic Potential
Ngoc Thi Minh Dinh1, Tuan Minh Nguyen1, Mi Kyung Park2
1College of Pharmacy, Dongguk University, Goyang 10326, Republic of Korea.
International Journal of Molecular Sciences
|January 23, 2024
Summary
Y-box binding protein 1 (YBX1) is an oncogene overexpressed in many cancers, driving tumor growth and impacting prognosis. Targeting YBX1 shows promise for novel cancer therapies, including in breast and lung cancers.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Y-box binding protein 1 (YBX1) is a Cold Shock Domain protein family member.
- YBX1 overexpression is linked to poor prognosis in various human cancers.
- YBX1 interacts with DNA and RNA, influencing diverse cellular processes.
Purpose of the Study:
- To comprehensively review YBX1's multifaceted role in cancer.
- To explore YBX1's involvement in cancer cell-autonomous functions and the tumor microenvironment.
- To propose YBX1 as a potential therapeutic target for cancer treatment.
Main Methods:
- Literature review of YBX1's function in cancer.
- Analysis of YBX1's role across cancer hallmarks.
- Summary of ongoing clinical trials and in vitro research targeting YBX1.
- Review of YBX1's emerging role in neuro-oncology and neurodegenerative diseases.
Main Results:
- YBX1 contributes to multiple cancer hallmarks.
- YBX1 is implicated in both cancer cells and the tumor microenvironment.
- Clinical trials and preclinical research support YBX1 as a therapeutic target.
- YBX1 is associated with nerve cancers and neurodegenerative diseases.
Conclusions:
- YBX1 is a promising therapeutic target for various cancers.
- Further research into YBX1 targeting compounds is warranted.
- YBX1's role in neurological conditions requires further investigation.
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