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The Multifaceted S100B Protein: A Role in Obesity and Diabetes?
Fabrizio Michetti1,2,3,4, Gabriele Di Sante5, Maria Elisabetta Clementi1
1Istituto di Scienze e Tecnologie Chimiche "Giulio Natta" SCITEC-CNR, L.go F. Vito 1, 00168 Rome, Italy.
Abstract:
The S100B protein is abundant in the nervous system, mainly in astrocytes, and is also present in other districts. Among these, the adipose tissue is a site of concentration for the protein. In the light of consistent research showing some associations between S100B and adipose tissue in the context of obesity, metabolic disorders, and diabetes, this review tunes the possible role of S100B in the pathogenic processes of these disorders, which are known to involve the adipose tissue. The reported data suggest a role for adipose S100B in obesity/diabetes processes, thus putatively re-proposing the role played by astrocytic S100B in neuroinflammatory/neurodegenerative processes.
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