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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood.
Allison B Reiss1, Shelly Gulkarov1, Aaron Pinkhasov2
1Department of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.
Medicina (Kaunas, Lithuania)
|January 23, 2024
Summary
Androgen deprivation therapy (ADT) for prostate cancer may impact cognitive function and mood. Shared genes between ADT patients and Alzheimer's patients suggest a potential link warranting further investigation.
Area of Science:
- Oncology
- Neurology
- Endocrinology
Background:
- Prostate cancer is a leading cause of cancer death in men.
- Androgen deprivation therapy (ADT) is a primary treatment for metastatic prostate cancer.
- ADT involves anti-androgen drugs that may affect cognitive function, mood, and quality of life.
Purpose of the Study:
- To review the effects of ADT on cognitive function, mood, and quality of life.
- To analyze the relationship between ADT and Alzheimer's disease.
- To explore shared genetic mechanisms between ADT and Alzheimer's disease.
Main Methods:
- Review of existing literature on ADT and its effects.
- Comparative analysis of gene expression in prostate cancer patients on ADT and Alzheimer's patients.
- Description of neurocognitive testing for evaluating cognitive ability in prostate cancer patients.
Main Results:
- ADT may lead to reduced white matter integrity and impact hypothalamic functions.
- Over 30 shared genes were identified between prostate cancer patients on ADT and Alzheimer's patients.
- ADT is associated with potential adverse effects on cognition, mood, and quality of life.
Conclusions:
- ADT may have significant physiological effects impacting cognitive function and mood.
- Shared genetic factors suggest a potential mechanistic link between ADT and Alzheimer's disease.
- Further research is needed to understand the relationship between hormonal changes, cognitive deficits, and mood disturbances.
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