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Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood

Allison B Reiss1, Shelly Gulkarov1, Aaron Pinkhasov2

  • 1Department of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA.

Medicina (Kaunas, Lithuania)
|January 23, 2024
PubMed

Insights

Androgen deprivation therapy (ADT) for prostate cancer may impact cognitive function and mood. Shared genes between ADT patients and Alzheimer's patients suggest a potential link warranting further investigation.

Area of Science:

  • Oncology
  • Neurology
  • Endocrinology

Background:

  • Prostate cancer is a leading cause of cancer death in men.
  • Androgen deprivation therapy (ADT) is a primary treatment for metastatic prostate cancer.
  • ADT involves anti-androgen drugs that may affect cognitive function, mood, and quality of life.

Purpose of the Study:

  • To review the effects of ADT on cognitive function, mood, and quality of life.
  • To analyze the relationship between ADT and Alzheimer's disease.
  • To explore shared genetic mechanisms between ADT and Alzheimer's disease.

Main Methods:

  • Review of existing literature on ADT and its effects.
  • Comparative analysis of gene expression in prostate cancer patients on ADT and Alzheimer's patients.
  • Description of neurocognitive testing for evaluating cognitive ability in prostate cancer patients.

Main Results:

  • ADT may lead to reduced white matter integrity and impact hypothalamic functions.
  • Over 30 shared genes were identified between prostate cancer patients on ADT and Alzheimer's patients.
  • ADT is associated with potential adverse effects on cognition, mood, and quality of life.

Conclusions:

  • ADT may have significant physiological effects impacting cognitive function and mood.
  • Shared genetic factors suggest a potential mechanistic link between ADT and Alzheimer's disease.
  • Further research is needed to understand the relationship between hormonal changes, cognitive deficits, and mood disturbances.
Keywords:
androgen deprivation therapycognitive functionhormonal therapiesmanagement strategiesprostate cancertestosterone

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