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Updated: Jun 11, 2026
07:32
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
11.3K
Tween 80-Based Self-Assembled Mixed Micelles Boost Valsartan Transdermal Delivery
Alaa Eldeen B Yassin1, Salam Massadeh2,3, Abdullah A Alshwaimi4
1College of Pharmacy, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.
Pharmaceuticals (Basel, Switzerland)
|January 23, 2024
Summary
This study developed valsartan (Val)-loaded mixed micelles for transdermal delivery. The optimized system significantly enhanced Val permeation through skin, offering a promising alternative for hypertension treatment.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Valsartan (Val) exhibits poor oral bioavailability due to low solubility and dissolution.
- Transdermal delivery offers potential for sustained drug levels and reduced side effects.
Purpose of the Study:
- To optimize mixed micelle systems for enhanced transdermal delivery of valsartan.
- To improve therapeutic performance by achieving prolonged, uniform drug levels.
Main Methods:
- Valsartan-loaded mixed micelles prepared via thin-film hydration and micro-phase separation.
- Optimization of surfactant type and drug-to-surfactant ratio.
- Characterization of micelle size, PDI, zeta potential, and entrapment efficiency (EE).
Main Results:
- High Val entrapment efficiency (>90%) and low particle charges achieved.
- Micellar sizes ranged from 107.6 to 191.7 nm with PDI values around 0.3.
- Formulation F7 showed significant transdermal efflux (68.84 ± 3.96 µg/cm²/h) with an enhancement factor of 16.57.
Conclusions:
- Successfully developed reproducible valsartan-loaded mixed micelles using simple methods.
- Demonstrated extensive transdermal delivery without harsh skin enhancers.
- Mixed micelles show potential for improved valsartan therapy via transdermal route.
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