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Related Experiment Video

Updated: Jul 5, 2025

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

Using Nutraceuticals to Help Manage Traumatic Spinal Cord Injury.

Paul Stacey^1,2, Arun Mensinkai^3,4, Pankaj Bansal^1,2

¹Department of Physical Medicine and Rehabilitation, Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada.

Pharmaceuticals (Basel, Switzerland)

|January 23, 2024

Summary

This pilot study found oral selenium and vitamin E safe for traumatic spinal cord injury (TSCI) patients. While not improving clinical scores, the treatment showed potential for future efficacy trials in TSCI management.

Keywords:

nutraceuticals selenium spinal cord injury tractography vitamin E

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Last Updated: Jul 5, 2025

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

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Published on: February 23, 2015

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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

Area of Science:

Neuroscience
Clinical Medicine
Nutritional Science

Background:

Traumatic spinal cord injury (TSCI) significantly impairs function, quality of life, and longevity.
Effective management of chronic conditions, including TSCI, is crucial in modern healthcare.
Current treatment options for TSCI often focus on symptom management and rehabilitation.

Purpose of the Study:

To evaluate the feasibility of treating individuals with chronic TSCI using oral selenium and vitamin E.
To assess the safety and tolerability of this combination therapy in a TSCI population.
To explore the potential of MRI tractography as a surrogate endpoint for treatment efficacy.

Main Methods:

An open-label, single-arm, prospective pilot study.
Participants (≥18 years) with TSCI (≥1 year post-injury) received daily oral selenium (50 mcg) and vitamin E (400 IU).
Radiologic (MRI tractography) and clinical (ASIA scores) assessments were performed at baseline and after one year.

Main Results:

Four subjects completed the 12-month study with approximately 75% adherence.
No adverse events related to selenium and vitamin E supplementation were reported.
Subjects reported some symptom improvement, but no significant changes in ASIA scores were observed. MRI tractography showed potential as a surrogate endpoint.

Conclusions:

Combination treatment with oral selenium and vitamin E is safe for patients with chronic TSCI.
MRI tractography may be a valuable tool for assessing injury extent and potentially monitoring treatment effects.
The findings support the feasibility of conducting larger clinical trials to determine the efficacy of selenium and vitamin E for TSCI.