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Targeted Cancer Therapies

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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

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Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent.

Muhammad Ali^1,2, Viviana Benfante^1,2, Domenico Di Raimondo²

¹Ri.MED Foundation, Via Bandiera 11, 90133 Palermo, Italy.

Pharmaceuticals (Basel, Switzerland)

|January 23, 2024

Summary

Resveratrol shows promise for cancer treatment, but nanoparticles enhance its delivery. Nanoparticle-based resveratrol improves bioavailability and anticancer efficacy compared to free resveratrol.

Keywords:

anticancer properties bioavailability nanoparticles polyphenolic compound resveratrol encapsulation

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Area of Science:

Biomedical Engineering
Nanotechnology
Pharmacology

Background:

Resveratrol, a polyphenol, exhibits anti-inflammatory and anticancer properties.
Its therapeutic use is limited by poor water solubility, low bioavailability, and rapid metabolism.
Nanoparticle delivery systems offer a solution to these limitations.

Purpose of the Study:

To review advancements in nanoparticle-based resveratrol delivery systems.
To highlight strategies for overcoming resveratrol's bioavailability and efficacy challenges.
To explore the potential of enhanced resveratrol formulations in cancer therapy.

Main Methods:

Review of existing literature on nanoparticle-based resveratrol delivery.
Analysis of various nanoparticle types used for resveratrol encapsulation or conjugation.
Evaluation of studies demonstrating improved resveratrol solubility, bioavailability, and anticancer activity.

Main Results:

Numerous nanoparticle platforms (e.g., liposomes, gold nanoparticles, mesoporous nanoparticles) have been developed for resveratrol delivery.
Resveratrol-loaded or conjugated nanoparticles significantly enhance water solubility and bioavailability.
Nanoparticle formulations demonstrate superior anticancer potency compared to free resveratrol in preclinical studies.

Conclusions:

Nanoparticle-based delivery systems are effective in overcoming the limitations of free resveratrol.
These advanced delivery systems hold significant potential for improving resveratrol's anticancer therapeutic effectiveness.
Further research into optimized nanoparticle formulations can unlock the full potential of resveratrol in cancer treatment.