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Infective Endocarditis Due to Kingella kingae

Raphael Joye1, Vladimir L Cousin1,2, Iliona Malaspinas1

  • 1Pediatric Cardiology Unit, Department of Woman, Child, and Adolescent Medicine, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.

Microorganisms
|January 23, 2024
PubMed

Insights

Kingella kingae endocarditis is a rare but severe infection, primarily affecting children. Advances in diagnostics improve detection, highlighting the need for understanding epidemiology and virulence factors for effective treatment.

Area of Science:

  • Infectious Diseases
  • Pediatric Cardiology
  • Microbiology

Background:

  • Kingella kingae endocarditis is an uncommon yet serious invasive infection.
  • This condition predominantly affects the pediatric population.
  • Recent diagnostic advancements include nucleic acid amplification testing and cardiac imaging.

Purpose of the Study:

  • To synthesize current knowledge on Kingella kingae endocarditis.
  • To cover epidemiological features, pathophysiology, complications, and therapy.
  • To identify knowledge gaps and future research directions.

Main Methods:

  • Comprehensive literature review.
  • Synthesis of existing data on Kingella kingae endocarditis.
  • Analysis of epidemiological trends, virulence, and treatment strategies.

Main Results:

  • Kingella kingae endocarditis, though rare, presents significant clinical challenges.
  • Improved diagnostic tools enhance early and accurate identification.
  • Understanding pathogen-specific factors is key for therapeutic guidance.

Conclusions:

  • A comprehensive understanding of Kingella kingae endocarditis is essential for effective management in both children and adults.
  • Further research is needed to address identified knowledge gaps.
  • Integrated approaches combining diagnostics and pathogen knowledge are crucial.

Keywords:
Kingella kingaecardiac imagingcardiac surgerychildreninfective endocarditisinvasive infection

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