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Long-Acting Injectable Antipsychotics-A Review on Formulation and In Vitro Dissolution
Magdalena Markowicz-Piasecka1, Marcin Kubisiak2, Katarzyna Asendrych-Wicik2,3
1Department of Applied Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.
Pharmaceutics
|January 23, 2024
Summary
Long-acting injectable (LAI) neuroleptics improve mental illness management by enhancing patient compliance and preventing relapses. This review examines LAI formulation, focusing on drug release profiles and in vitro-in vivo correlations for quality assurance.
Area of Science:
- Pharmacology
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Long-acting injectable (LAI) neuroleptics offer a vital treatment option for persistent mental illnesses.
- LAIs improve patient outcomes by ensuring consistent medication delivery, reducing relapse rates, and enhancing treatment adherence.
Purpose of the Study:
- To review the formulation characteristics of LAI neuroleptics.
- To emphasize the critical role of drug release profiles in ensuring pharmaceutical quality and therapeutic efficacy.
- To discuss the established and emerging methods for assessing in vitro-in vivo correlations (IVIVC).
Main Methods:
- Literature review of current LAI neuroleptic formulations.
- Analysis of various dissolution testing methodologies employed by manufacturers.
- Examination of in vitro-in vivo correlation (IVIVC) studies and their significance.
Main Results:
- LAI neuroleptics are crucial for managing chronic mental health conditions.
- Drug release profiles are essential quality control parameters for LAIs.
- Dissolution tests, though varied, are key for predicting in vivo performance.
Conclusions:
- Formulation analysis, particularly drug release testing, is paramount for LAI neuroleptic quality.
- Robust in vitro-in vivo correlation (IVIVC) is necessary to ensure the therapeutic effectiveness of LAI formulations.
- Standardized testing procedures would further enhance the reliability of LAI neuroleptics.
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