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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

248
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
248
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

187
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
187
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

127
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
127
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

139
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
139
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

455
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
455

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Related Experiment Video

Updated: Jul 5, 2025

Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Intestinal Membrane Function in Inflammatory Bowel Disease.

Daisuke Nakai1, Masateru Miyake2

  • 1Drug Metabolism & Pharmacokinetics Research Laboratory, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Pharmaceutics
|January 23, 2024
PubMed
Summary

Altered gastrointestinal membrane permeability in inflammatory bowel diseases like ulcerative colitis and Crohn's disease impacts oral drug effectiveness. Research using gut-on-a-chip models advances understanding for better treatment strategies.

Keywords:
Crohn’s diseaseUssing chamberelectrophysiological parameterinflammatory bowel diseasepermeabilityulcerative colitis

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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
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An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
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Related Experiment Videos

Last Updated: Jul 5, 2025

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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

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An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
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An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

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Area of Science:

  • Gastroenterology
  • Pharmacology
  • Biomedical Engineering

Background:

  • Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, involves chronic gastrointestinal inflammation.
  • Gastrointestinal membrane permeability significantly influences oral drug efficacy for IBD and other conditions.
  • Understanding disease-related pharmacokinetic changes is crucial for effective pharmacotherapy.

Purpose of the Study:

  • To review gastrointestinal membrane function in ulcerative colitis and Crohn's disease.
  • To analyze in vitro membrane permeability and electrophysiological parameters in IBD.
  • To summarize in vivo human permeability data and explore gut-on-a-chip applications in IBD research.

Main Methods:

  • Review of in vitro membrane permeability studies in IBD models.
  • Analysis of electrophysiological parameters related to gastrointestinal function in IBD.
  • Compilation of in vivo human permeability data.
  • Overview of gut-on-a-chip technologies for IBD modeling.

Main Results:

  • IBD significantly alters gastrointestinal membrane permeability and function.
  • In vitro and in vivo data highlight changes in drug transport mechanisms.
  • Gut-on-a-chip models show promise in recapitulating IBD pathophysiology and drug responses.

Conclusions:

  • Altered gastrointestinal membrane function in IBD affects drug pharmacokinetics.
  • Advanced models like gut-on-a-chip offer new avenues for IBD research.
  • Findings support the development of optimized therapeutics and treatment regimens for IBD.