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Lipid-Based Nanotechnology: Liposome.

Yanhao Jiang1, Wenpan Li1, Zhiren Wang1

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|January 23, 2024
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Summary
This summary is machine-generated.

Liposomes offer versatile drug delivery but face challenges like leakage. This review covers liposome advantages, preparation, and FDA-approved nanotherapeutics for disease treatment.

Keywords:
disease treatmentsdrug deliveryliposome

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Liposomes are widely used in pharmaceutical, cosmetic, and dietetic fields due to their biocompatibility and biodegradability.
  • They can enhance the therapeutic index of free drugs, offering significant clinical advantages.
  • However, challenges such as premature leakage and manufacturing issues hinder their full potential.

Purpose of the Study:

  • To review the advantages, compositions, and preparation techniques of liposomes.
  • To discuss current U.S. FDA-approved, clinical, and preclinical liposomal nanotherapeutics.
  • To summarize the significance and challenges in liposome-enabled nanotherapeutic development.

Main Methods:

  • Literature review of liposome applications and nanotherapeutics.
  • Analysis of U.S. FDA-approved and clinical-stage liposomal drugs.
  • Discussion of liposome preparation methods and challenges.

Main Results:

  • Liposomes demonstrate versatility and biocompatibility, enhancing drug delivery.
  • Various liposomal nanotherapeutics are approved or in clinical trials for diverse diseases.
  • Key challenges include premature leakage, manufacturing consistency, and translation success.

Conclusions:

  • Liposomes are crucial in pharmaceutical advancement, offering enhanced drug delivery.
  • Addressing current challenges is vital for expanding liposomal nanotherapeutics.
  • This review provides foundational knowledge on liposomes for future development.