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Core-Shell Microspheres Prepared Using Coaxial Electrostatic Spray for Local Chemotherapy of Solid Tumors
Xiaowei Zhang1,2, Rundong Zhu1, Xingzhi Wang1
1State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Pharmaceutics
|January 23, 2024
Summary
This study introduces a simple method for preparing paclitaxel-loaded microspheres (PTX-CA/PLGA-MS) for local chemotherapy. These novel microspheres demonstrate effective tumor suppression with reduced organic solvent use.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Local chemotherapy offers targeted drug delivery, minimizing systemic side effects.
- Drug-loaded microspheres are effective for sustained drug release in local chemotherapy.
- Complex preparation methods hinder the development of microsphere formulations.
Purpose of the Study:
- To develop a simple and efficient method for preparing core-shell structured paclitaxel-loaded microspheres.
- To evaluate the in vitro and in vivo performance of these novel microspheres for local chemotherapy.
Main Methods:
- Utilized coaxial electrostatic spray technology for fabricating paclitaxel-loaded calcium alginate/poly (lactic acid-co-glycolic acid) core-shell microspheres (PTX-CA/PLGA-MS).
- Assessed drug release profiles and anti-tumor efficacy in animal tumor models.
Main Results:
- PTX-CA/PLGA-MS demonstrated a two-stage drug release pattern.
- The microspheres significantly enhanced anti-tumor effects in vivo.
- The preparation method is simple and substantially reduces organic solvent consumption.
Conclusions:
- Coaxial electrostatic spray technology provides a simplified approach for producing paclitaxel-loaded core-shell microspheres.
- PTX-CA/PLGA-MS are promising for local chemotherapy due to their sustained release and enhanced anti-tumor activity.
- This method offers an environmentally friendlier alternative for microsphere formulation.
