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Improving Inhalation Performance with Particle Agglomeration via Combining Mechanical Dry Coating and Ultrasonic
Qingzhen Zhang1, Zheng Wang1,2, Kaiqi Shi3
1Department of Chemical and Environmental Engineering, University of Nottingham Ningbo China, Ningbo 315100, China.
Pharmaceutics
|January 23, 2024
Summary
Improving budesonide dry powder inhalation (DPI) formulations with surface-modified lactose agglomerates and ultrasonic vibration enhances aerosol performance. This approach reduces upper airway deposition and potential side effects for better therapeutic outcomes.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Agglomerate formulations for dry powder inhalation (DPI) are crucial for efficient budesonide delivery.
- Uncontrolled agglomeration leads to high upper airway deposition, local side effects, and poor fine-particle delivery.
Purpose of the Study:
- To improve aerosol performance of budesonide agglomerates via surface modification and ultrasonic spheroidization.
- To reduce mechanical strength and cohesive forces in agglomerates for enhanced deagglomeration and fine-particle fraction (FPF).
Main Methods:
- Fine lactose particles were mechanically dry-coated with hydrophobic magnesium stearate.
- Agglomerates were subsequently spheroidized using ultrasonic vibration.
- Aerosol performance was evaluated using a Turbuhaler® and pharmaceutical cascade impactor.
Main Results:
- The optimized agglomerates exhibited lower mechanical strength and reduced cohesive forces.
- Improved fine powder dispersion behavior was observed.
- A high fine particle fraction (FPF) of 71.1 ± 1.3% and low artificial throat deposition of 19.3 ± 0.4% were achieved.
Conclusions:
- Surface modification with magnesium stearate and ultrasonic vibration significantly enhance budesonide agglomerate aerosolization.
- This strategy holds potential for improving therapeutic efficacy and reducing local side effects in the mouth and pharynx.
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