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Related Experiment Video

Updated: Jul 5, 2025

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
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Construction Strategy of Functionalized Liposomes and Multidimensional Application.

Chengyun Wang1,2,3, Xinyue Lan3, Longjiao Zhu3

  • 1College of Food Science and Nutritional Engineering, China Agricultural University, No. 17, Qinghua East Road, Beijing, 100083, China.

Small (Weinheim an Der Bergstrasse, Germany)
|January 23, 2024
PubMed
Summary

Functionalized liposomes offer enhanced biocompatibility and surface modification for biological applications. This review details strategies for binding nucleic acids, antibodies, and peptides to liposomes, addressing in vivo challenges and future industrialization.

Keywords:
construction strategydrug deliveryfunctional nucleic acidfunctionalized liposomesstimulus responsetarget

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Area of Science:

  • Biochemistry
  • Material Science
  • Nanotechnology

Background:

  • Liposomes are versatile nanocarriers with excellent biocompatibility and surface modifiability.
  • Advancements in biochemistry and material science have propelled liposomes from traditional to functionalized and intelligent platforms.
  • In vivo environmental complexity poses a significant challenge to liposome efficiency.

Purpose of the Study:

  • To summarize binding strategies of liposomes with key functional elements: nucleic acids, antibodies, peptides, and stimuli-responsive motifs.
  • To provide a comprehensive overview of functionalized liposome features and research progress.
  • To critically assess current limitations and propose future directions for liposome industrialization.

Main Methods:

  • Literature review and synthesis of binding strategies for functionalizing liposomes.
  • Analysis of functionalized liposome characteristics, including drug carrying, targeting, circulation time, and stimulus-responsiveness.
  • Critical evaluation of current applications and future prospects.

Main Results:

  • Detailed summary of liposome conjugation strategies with nucleic acids, antibodies, peptides, and stimuli-responsive elements.
  • Overview of enhanced properties of functionalized liposomes: drug delivery, targeting, prolonged circulation, and responsiveness.
  • Identification of limitations in current applications and potential solutions.

Conclusions:

  • Functionalized liposomes represent a promising strategy to overcome in vivo limitations.
  • Further research and development are crucial for the industrialization of advanced liposome platforms.
  • This review provides a roadmap for future advancements in functionalized liposome technology.