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Related Experiment Video

Updated: Jun 23, 2026

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation

Published on: April 27, 2019

Beating Heart Transplantation: How to Do It.

Aravind Krishnan¹, Brandon A Guenthart¹, Chawannuch Ruaengsri¹

¹Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA, USA.

Innovations (Philadelphia, Pa.)

|January 23, 2024

Summary

A novel beating heart implantation technique for deceased after circulatory death (DCD) donors eliminates cardioplegic arrest, potentially improving heart transplant outcomes. This method aims to match results from brain death donors, reducing ischemia and reperfusion injury.

Keywords:

ex vivo organ perfusion heart transplantation organ preservation

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Last Updated: Jun 23, 2026

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation

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Published on: April 27, 2019

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

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Published on: February 14, 2022

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

Area of Science:

Cardiovascular Surgery
Organ Transplantation
Donor Management

Background:

Deceased after circulatory death (DCD) donors expand the organ donor pool for heart transplantation.
Conventional DCD heart transplantation involves warm and cold ischemia, potentially impacting outcomes.
Ex vivo normothermic perfusion is a key technology in utilizing DCD hearts.

Purpose of the Study:

To introduce and detail a novel beating heart implantation technique for DCD heart transplantation.
To eliminate the need for a second cardioplegic arrest and associated reperfusion injury.
To hypothesize improved short-term and long-term outcomes comparable to brain death donor transplants.

Main Methods:

Development of a beating heart implantation surgical technique.
Application of the technique in deceased after circulatory death (DCD) heart transplantation.
Focus on avoiding a second cardioplegic arrest during implantation.

Main Results:

The developed technique successfully enables beating heart implantation.
Eliminates the requirement for cardioplegic arrest and subsequent reperfusion injury.
Provides a reproducible method for DCD heart transplantation.

Conclusions:

The beating heart implantation technique offers a promising alternative for DCD heart transplantation.
Potential to improve patient outcomes by mitigating ischemic injury.
This method may help achieve outcomes similar to those from brain death donors.