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Left ventricular function during alcohol intoxication and autonomic nervous blockade.

H Kelbaek, T Gjørup, O J Hartling

The American Journal of Cardiology

|March 1, 1987

Summary

This summary is machine-generated.

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Alcohol intoxication depresses left ventricular function at rest, increasing heart rate and decreasing ejection fraction. Sympathetic nervous activity during exercise is a toxic effect of alcohol.

Area of Science:

Cardiology
Exercise Physiology
Pharmacology

Background:

Alcohol consumption can affect cardiovascular function.
Autonomic nervous system plays a crucial role in regulating heart function during rest and exercise.

Purpose of the Study:

To investigate the effects of alcohol intoxication on left ventricular (LV) function.
To examine the role of autonomic nervous blockade in modulating alcohol's cardiovascular effects.
To assess sympathetic nervous system activity during alcohol intoxication and exercise.

Main Methods:

Eight healthy young subjects underwent radionuclide cardiography at rest and during exercise.
Measurements were taken during alcohol intoxication and after autonomic nervous blockade (metoprolol and atropine).

Related Experiment Videos

Plasma norepinephrine and epinephrine concentrations were measured.

Main Results:

Alcohol intoxication increased resting heart rate and decreased LV ejection fraction due to end-systolic dilation.
No significant alcohol-induced hemodynamic changes occurred during exercise.
Autonomic blockade did not significantly alter alcohol's effects compared to a control.
Plasma norepinephrine levels were elevated at rest and during exercise during alcohol intoxication.

Conclusions:

Alcohol intoxication exerts a depressant effect on resting LV function.
Increased sympathetic nervous activity during exercise under alcohol intoxication appears toxic, not compensatory.
Autonomic nervous blockade did not mitigate the observed cardiovascular effects of alcohol.