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KIO3-catalyzed selective oxidation of thiols to disulfides in water under ambient conditions
José R L Sousa1, Marcelo S Franco1, Leila D Mendes1
1LabSelen, Departamento de Química, Universidade Federal de Santa Catarina - UFSC, Florianópolis, 88040-900, SC, Brazil. braga.antonio@ufsc.br.
Abstract:
Herein, we report a KIO3-catalyzed oxidative coupling of thiols to their corresponding disulfides in water, in a short time and at ambient temperature. The reaction has a broad scope and exhibits good functional group tolerance, resulting in the desired products in excellent yields. This approach allows the reuse of the reaction system in multiple cycles and scale-up. Furthermore, the current protocol demonstrates compatibility for in situ generation of disulfides and post application in C(sp2)-H bond sulfenylation.
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