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Case report: Overlapping anti-AMPAR encephalitis with anti-IgLON5 disease post herpes simplex virus encephalitis

Shihui Sun1, Jiafeng Ren1, Zhao Zhong1

  • 1Department of Neurology, the Second Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi, China.

Frontiers in Immunology
|January 23, 2024
PubMed

Keywords:
anti-AMPAR encephalitisanti-IgLON5 diseaseautoimmune encephalitisherpes simplex virus 1overlap

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Cytomegalovirus Disease

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Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...