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Methods for Analyzing the Impacts of Natural Uranium on In Vitro Osteoclastogenesis

Methods for Analyzing the Impacts of Natural Uranium on In Vitro Osteoclastogenesis

Published on: January 30, 2018

Association between urine uranium and asthma prevalence.

Dongdong Huang¹, Saibin Wang²

¹Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China.

Frontiers in Public Health

|January 23, 2024

Summary

Urine uranium (U) levels are linked to increased asthma prevalence in the U.S. general population. This association is stronger in individuals with higher education levels.

Keywords:

NHANES asthma environmental pollution heavy metal uranium

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Area of Science:

Environmental Health
Epidemiology
Toxicology

Background:

Previous research indicated a link between urine uranium (U) and adult asthma.
The association in the general population remained unclear.

Purpose of the Study:

To investigate the association between urine uranium levels and asthma prevalence in the general population.
To explore potential modifying factors, such as education level, on this association.

Main Methods:

Utilized data from the 2007-2016 National Health and Nutrition Examination Survey (NHANES) in the United States.
Employed multiple regression analysis to assess the association between urine U and asthma prevalence.
Conducted subgroup analyses based on educational attainment to evaluate interaction effects.

Main Results:

A total of 13,581 participants were analyzed.
Uranium levels in urine (LnU) were independently and positively correlated with asthma prevalence (OR = 1.12; 95% CI: 1.04-1.20; p = 0.002).
The positive association was significantly stronger among individuals with a college education or higher (OR = 1.32; 95% CI: 1.11-1.57; P interaction = 0.0389).

Conclusions:

Urinary uranium levels are positively associated with asthma prevalence in the U.S. general population.
This association is particularly pronounced in individuals with higher educational attainment.
Findings suggest environmental uranium exposure may contribute to asthma burden, especially in educated demographics.