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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Causal association between obesity and hypothyroidism: a two-sample bidirectional Mendelian randomization study.

Yingkun Qiu1, Qinyu Liu2, Yinghua Luo2

  • 1Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, China.

Frontiers in Endocrinology
|January 23, 2024
PubMed
Summary

Obesity, including high body mass index (BMI) and waist circumference (WC), increases the risk of developing hypothyroidism. Losing weight is crucial for reducing this risk.

Keywords:
Mendelian randomizationbody mass indexhypothyroidismobesitywaist circumference

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Area of Science:

  • Genetics and Endocrinology
  • Metabolic and Endocrine Disorders

Background:

  • Observational studies suggest a link between obesity and hypothyroidism susceptibility.
  • Limited evidence exists to establish a definitive causal relationship using alternative methodologies.

Purpose of the Study:

  • To investigate the causal relationship between obesity and hypothyroidism.
  • To explore the bidirectional association between obesity-related traits and hypothyroidism.

Main Methods:

  • Employed a two-sample bidirectional Mendelian randomization (MR) analysis.
  • Utilized single-nucleotide polymorphisms (SNPs) for obesity traits from GWAS data.
  • Obtained hypothyroidism diagnostic data from the UK Biobank; analyzed using inverse variance-weighted (IVW) method.

Main Results:

  • Body mass index (BMI) and waist circumference (WC) significantly increased the odds and risk of hypothyroidism.
  • Genetic predisposition to hypothyroidism was associated with increased BMI and WC.
  • No significant association was found between WC adjusted for BMI (WCadjBMI) and hypothyroidism.

Conclusions:

  • Obesity is confirmed as a significant risk factor for hypothyroidism.
  • Individuals with higher BMI and WC face an elevated risk of developing hypothyroidism.
  • Weight loss interventions are important for mitigating hypothyroidism risk.