Composition of the CD27+ Memory-B-Cell Compartment Delineates Immunoglobulin Deficiency Endotypes
Oliva Starich1, Jared M Rieck2, Wyatt J Tarter2
1University of Colorado School of Medicine.
Research Square
|January 23, 2024
Summary
Reduced class-switched memory B cells (CSM) correlate with lower IgG and IgA in humoral immunodeficiencies. This finding aids in classifying these conditions and understanding B cell dysfunction.
Area of Science:
- Immunology
- Clinical Diagnostics
Background:
- Reduced class-switched memory B cells (CSM) are key in diagnosing Common Variable Immunodeficiency (CVID).
- Limited data exists on CSM in broader Primary Antibody Deficiencies (PADs).
Approach:
- Analyzed B cell panel results from 64 subjects with or without humoral immunodeficiency.
- Correlated CD27+IgM-IgD- B cell percentages (CSM%) with serum immunoglobulin levels.
Key Points:
- CSM% below 9.7% strongly correlated with significantly lower IgG and IgA levels.
- CSM% did not correlate with IgM levels; IgMonly B cell proportion correlated with serum IgM.
Conclusions:
- Low CSM% may indicate a specific endotype of humoral immune dysfunction.
- This stratification method can guide future research into B cell response failures in PADs.
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