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Updated: Jul 5, 2025
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A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence
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Approaching pathogenic Clostridia from a One Health perspective.
Laura M Cersosimo1, Jay N Worley1,2, Lynn Bry1,3
1Massachusetts Host-Microbiome Center, Dept. Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA.
Biorxiv : the Preprint Server for Biology
|January 23, 2024
Summary
Spore-forming pathogens persist in diverse environments, necessitating a One Health approach. Genomic data aids in tracking outbreaks and understanding disease, improving public health and food safety.
Area of Science:
- Microbiology
- Genomics
- Public Health
Background:
- Spore-forming pathogens exhibit remarkable environmental persistence and adaptability.
- Their ability to sporulate allows survival in various conditions, posing risks to human and animal health.
- A One Health approach is crucial for managing these pathogens across interconnected ecosystems.
Conclusions:
- Genomic data sharing is vital for enhancing global resources and developing impactful applications.
- Leveraging genomic surveillance improves understanding of pathogen reservoirs and transmission.
- These advancements inform strategies for disease prevention, treatment, and public health interventions.
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